Key Imaging Technology Dynamic Contrast Enhanced MRI (DCE-MRI) in Drug Development
Mark A. Rosen, MD, Ph.D. Assistant Professor of Radiology University of Pennsylvania Medical Center
Background
It has long been understood that tumors must establish their own blood supply in order to grow, and that tumors elicit angiogenic factors to recruit new blood vessel growth. Anti-tumor therapies targeted specifically against tumor neovessels and angiogenic pathways are now in routine use in human oncology trials and in the clinic. Non-invasive means to determine the status of tumor neo-vessels would improve our ability to determine functional tumor responsiveness to these agents. Dynamic contrast enhanced MRI (DCE-MRI) is one such method that has been used successfully for these purposes.
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