Description
Adare provides technologies to enable and improve the solubility of drugs with low solubility or an extreme pH-dependent solubility profile. The resulting formulations can offer effective oral dosing of poorly soluble drug candidates, equivalent therapy at lower doses, faster onset of action, and minimization of food effect. The solubility enhancement technologies provided by Adare include Diffucaps® solid solution or solid dispersion.
How It Works
A solid-solution/solid dispersion drug form is contained in layers of excipients and release-controlling polymers. This is combined with a crystallization inhibitor, enhancing bioavailability by maintaining the drug in its amorphous state. The solubility-enhanced beads can be coated with one or more functional polymers to achieve extended-release profiles suitable for once- or twice-daily dosing.
Our innovative solubility enhancement technologies provide:
Substantial global experience in all aspects
Effective oral dosing of poorly soluble drug candidates
Equivalent therapy at lower doses
Faster onset of action
Minimization of food effect
Adjustable dosage strength and dissolution profile to achieve the desired in vivo pharmacokinetic profile
Enhanced drug solubility in sections of the gastrointestinal tract through combined use with other Adare technologies
Solubility Enhancement Technologies
Bench-to-pilot scale Spray-drying
Hot Melt (Leistritz ZSE 18)
Dyno-mill
Diffucaps
Conventional approaches using:
Cyclodextrins
Solubilizers
Surfactants
Super-disintegrants