Creative Biolabs is your dedicated partner in anti-tumor drug discovery, offering access to a comprehensive range of validated and well-characterized xenograft models. These models are integral to evaluating the in vivo efficacy of novel anti-tumor therapeutics and providing critical decision-making information to advance your novel agents toward clinical trials. Our experienced preclinical team is ready to assist you in establishing the most appropriate xenograft tumor model and screening method tailored to your specific research needs.
The Power of Xenograft Models in Preclinical Oncology - For years, mouse tumor models, particularly xenografts, have been indispensable for verifying the in vivo efficacy of anti-tumor therapeutics before human clinical trials. Xenograft models, typically grown in immunodeficient mice (e.g., nude) or severe combined immune deficient (SCID) mice, are the most commonly used models for antineoplastic agent screening. These strains exhibit a high acceptance rate for xenografts, making them ideal for in vivo culture of human tumors.
Versatile Applications of Xenograft Models - Xenograft tumor models, typically established by subcutaneous inoculation of tumor cells, serve various crucial applications, including determining therapeutic schedules, drug dosages, and administration routes. The ultimate goal is maximizing anti-tumor efficacy and optimizing the therapeutic window.Creative Biolabs offers the following types of xenograft tumor models:
- Cell Line Derived Tumor Xenograft (CDX) Mouse Models: CDX models are a vital step in antineoplastic agent discovery and are widely used for preclinical testing of drug efficacy, PK/PD correlation studies, and combination therapy assessments.
- Patient-Derived Tumor Xenograft (PDTX) Mouse Models: PDTX models (also known as PDX models) involve transplanting primary tumors directly from patients into immunodeficient mice, offering a more clinically relevant model that closely mimics the original patient tumor.
- Nude Rat Xenograft Models: Nude rat xenograft models offer an attractive alternative to mouse models, particularly because the pharmacokinetic (PK) properties of agents in nude rats often more closely resemble those observed in humans.
Why Choose Creative Biolabs for Your Xenograft Studies?
Creative Biolabs provides a broad set of xenograft tumor models to ensure diverse assessment options for your oncology agent. Our scientists evaluate the xenograft tumor models on a regular basis for the assurance of qualified care standards, which can help you study complete profiling of agents. Choosing Creative Biolabs offers several advantages:
- Expert Guidance: Our team helps you select the most appropriate tumor model for your specific research objectives.
- Quality Assurance: Regular model evaluation ensures qualified care standards and reliable results.
- Comprehensive Profiling: Facilitate complete profiling of your agents using well-characterized models.
Beyond Xenografts: Rodent Tumor Models Aiming at providing the most effective and accurate way for our clients to evaluating novel drugs, Creative Biolabs also offers various well-validated rodent tumor models.
Partner with Creative Biolabs for Preclinical Success - Creative Biolabs is committed to providing the most effective and accurate tools for evaluating novel drugs. Contact us today to learn more about their xenograft models and other drug discovery services, and to receive exclusive technical support for your research endeavors. Creative Biolabs strives to be your trusted partner in preclinical oncology research, accelerating the development of innovative anti-tumor therapies.